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mavacamten will lessen the level or effect of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may possibly minimize systemic exposures of ethinyl estradiol and progestin, which may produce contraceptive failure or an increas